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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

When faced with competition, they may focus less on winning or losing than their Type A counterparts, and more on enjoying the game regardless of winning or losing.
Most technology developers are seeing app use grow and web use decline. That means companies have to have strong, fast, meaningful mobile platforms and those that don't lose customers.

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

从投资决策角度来看,2014年是有史以来最糟糕的年景之一,几乎可以说是全盘皆输。除了少数华尔街亿万富豪才玩得起的“股东积极主义”维权策略还算奏效外,没有哪种投资策略在这一年里始终灵光。
“让人们感到不幸福的原因有很多——从贫穷,失业,家庭破碎到身体伤害” 报告声称,“但在一些特定的社会中,慢性的精神性疾病却是幸福的‘头号杀手’。如果我们想要一个更加幸福的世界,我们需要花更多努力来关心人们的心理健康。”

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

From the themed collection: 中国塑钢型材市场的新趋势
Open Access Perspective

Soft matter science and the COVID-19 pandemic

11月22日,马拉比在伦敦的一场晚宴上领取了该奖。英国电信集团TalkTalk行政总裁迪多.哈丁(Dido Harding)应邀在晚宴上发表了演讲。

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

4. Precious metals: 'Going dark! Economic cycles point downward'

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

As a national exam with more than 1 million test takers every year, the National Postgraduates Entrance Examination is very important for students' academic life, and cheating incidents have been exposed from time to time.
9.Be Honest
尽管辩论被认为是仅仅关于外交政策的,但国内关注从未远离表面,候选人抓住每一个机会围绕他们的竞选演说在经济和税收方面给予攻击。之后在旋转屋也是一样,两个竞选团队很快分配着辩论评论,同时转到摇摆州中的竞争状态分析。
China becomes the first middle-income country to join the ranks of the world's 25 most-innovative economies, according to the Global Innovation Index (GII) released last Monday.

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

《一位德国女权主义先锋在痛苦中回顾过去》(A Pioneering German Feminist Looks Back in Anguish)
A child prodigy with an IQ higher than Albert Einstein is celebrating becoming a unique member of Mensa. Nishi Uggalle, ten, is one of the youngest people in the country to score the highest possible mark of 162 in the IQ society's supervised testing.
有些热门剧已经走得太远,应该降降温了,却仍在大张旗鼓,比如《唐顿庄园》(Downton Abbey)、《丑闻》(Scandal)和《复仇》(Revenge)。ABC频道的新剧《逍遥法外》(How to Get Away With Murder)是一部有趣的替代品,它是一部耸人听闻的夜间肥皂剧,讲述不法辩护律师的故事,简直可以称为“法律与无序”。
无从业资格的司机从事网约车服务将面临1万(折合1500美元)至3万元(折合4500美元)的罚款。

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

如果你的确需要招募很多自由职业者来为你打短工,那么你或许考虑过,干脆把服务外包流程也外包出去。市面上有好几家不错的公司从事这样的服务,每家都有不同的业务模式。比如,Bolton Remote公司能为你组织起一支经过审查的离岸承包商队伍。另一家提供商Hubstaff会评估你的项目,然后为你匹配合适的项目专家。使用就业外包服务可以节省你的时间,从而让你不必自己从事招募这一套流程。这些公司一般提供免费的招聘和就业外包服务,但是会从计时工资中抽取一定提成。

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

将第1题到第9题的分数相加,计算自己在“消极情感”维度的得分。

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
From the themed collection: 发改委:坚决遏制房价上涨
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

1.《刺客聂隐娘》(The Assassin)与《疯狂的麦克斯4:狂暴之路》(Mad Max: Fury Road),并列。侯孝贤和乔治·米勒(George Miller)导演了今年最好的两部商业片,二者都应该到你能找到的最大的屏幕上去看。
2. 美国页岩油。截至2014年底,美国页岩油日产量已经超过900万桶,比2007年增加了80%。这些页岩油是造成石油供给过剩的主要力量,而供过于求是2014年油价暴跌的诱因之一。总的来说,美国页岩油开采公司都搬起石头砸了自己的脚,但关键在于,西德州轻质低硫原油(WTI)价格跌破60美元对它们有何影响?页岩油钻机数量不断减少,相关开支也遭到削减,然而到目前为止,美国页岩油产量依然稳定。按照当前油价,这个行业能否维持产出水平,或者说美国页岩油产量会不会减少将对国际市场供应乃至油价产生重大影响。

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

In addition, the 1980 stamps were designed by Huang Yongyu, 92, a well-known Chinese master painter, making it a collectible item with extreme value.
汽车销量:2015年,汽车销量将达到1700万辆,但随着皮卡和SUV的走俏,各大厂商也会纷纷调整产能。低油价的压力将导致小型车的利润更加单薄。

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

“我跟她很像,我们真的就像一对老夫妇。”
销量高峰每日售票量约1500万张,每秒售出近700张车票。

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

4. The 2012 Ig Nobel Neuroscience Prize
一,中国航空发动机集团的成立。去年集团公司通过研发提高了国产发动机的技术水平与续航能力,表明自主开发飞机发动机仍是当前中国的战略重点。当中国获得了铼,一种制造高压喷气发动机涡轮叶片的必须合金材料之后,这一决心更加显著。2010年在陕西发现占世界总储量7%的铼矿后,中国已投入相当大的精力开采并应用这一金属。此外,现代喷气发动机的关键部件——大规模单晶涡轮叶片制造技术也取得了重大突破。新成立的中俄宽体客机项目至此有望用上国产发动机。
Three Billboards Outside Ebbing, Missouri is a darkly comic drama from Academy Award winner Martin McDonagh.
库什纳回忆道,我当时被他深深折服了。他到新闻集团去见默多克时,我与他有了第一次接触,当时我被一同叫去提提意见。达洛伊西奥在会上描述了他想要实现的远景。他帮助默多克加深了对一些事物的见解。达洛伊西奥在台上的优异表现,加上背后李嘉诚的雄厚财力,为Summly招来了包括艾什顿?库奇(Ashton Kutcher)、小野洋子(Yoko Ono)、史蒂芬?弗莱(Stephen Fry)等许多人的捐赠。

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

一名校友表示:我们被迫远离了安逸,但获得了独特的体验。

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

Dachis says: Adidas added more than 34 million new fans and followers in just 12 months this year. The company put that audience to good use and benefited from high levels of positive discussion all year long.
Wang Jie, the general manager of a Beijing-based investment company, said the higher pay for executives in the financial and real estate industries shows the imbalance of development in China.

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

"这个家伙对当前情况作了利弊权衡:他有很大机会从故障电梯逃生,但是如果家庭作业没完成,他会很倒霉。"一名名为Zealshifang的用户调侃道。

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

As consumers in developing countries continue to shift to meat-based diets, grains and oilseeds used as livestock feed are expected to see support.

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

不过目前来看,这些潜在的乌云似乎都没有遮住特斯拉在帕洛阿尔托总部的阳光。特斯拉仍然坚持在2020年之前年产50万辆汽车的中期目标。这在很大程度上要取决于Model X是否有能力维持当前的势头。特斯拉已经大大提高了资本和研发支出,以确保Model X的顺利发布(虽然已经推迟了一年)。
他说,到1997-98年亚洲金融危机爆发时,美联储的回应已变得更加迅速,它退出了紧缩周期,担心东南亚的动荡会影响美国经济。
She had recently emerged as the right hand of her father, the former Prime Minister Nawaz Sharif. But corruption charges are clouding her rapid rise.
根据声明,通州新的行政中心将把基础设施升级和生态建设放在首位。北京市政府希望可以提高该地区的教育、医疗、文化事务与产业在内的公共服务发展。

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

It was visible in practically every brand that edged from the 1960s to 1970s for the season currently in stores, including Alberta Ferretti, Pucci and Etro.
7.Make Practice Tests
Housing started last year on a high note. It ended the year facing mounting worries about higher interest rates, supply constraints, tight credit and a host of other problems.
The actress who kick-started the exposure of Hollywood moguls who allegedly exploited positions of power to abuse women has branded #MeToo campaigners against sex attackers 'losers'.
“The auction market is extremely selective,” said Henry Pettifer, the head of old master paintings at Christie’s, whose sale total had been dented by a 15th-century Flemish Madonna and child by Hans Memling that the auction house had sold privately for more than 3.5 million and had withdrawn from the sale. “The availability of fresh material is limited,” he added, alluding to how few museum-quality works are in private hands.

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

中国的网红经济发展到今天,经历了三个阶段:第一个阶段是文字时代,第二个阶段是图文时代,现在这一阶段是要归功于宽带的可用性的视频时代。
The findings of the US and UK scientists are based on thousands of global temperature measurements taken daily on land and at sea.

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

The other two manufacturers, OPPO and vivo, both achieved growth of over 100 percent, shipping 99.4 million and 77.3 million units respectively in 2016.

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

P2P lending has grown quickly in the past two years, with loans outstanding reaching Rmb209bn by the end of June, according to E-Lending House.

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

This groundbreaking fight is loosely based on a bout between Chuck Wepner and Muhammad Ali, in which the "everyman" Wepner managed to become one of the four men to knock Ali down in his career. Just like in the film, Wepner pushed Ali through 15 rounds despite looking (and feeling) like he'd been hit by a truck. While both he and Rocky ended up losing their fights on a technicality, Wepner wins in our book for inspiring such an awesome character.
Song “Chang’er”(Li Yugang and three Chinese astronauts)
科技界的女性:科技行业今年第二度作为权势女性榜上的一个分类。前25位最有权势的女性中,5位来自科技行业,包括Facebook的雪莉·桑德伯格(桑德伯格新书《Lean In》下载>>)(排名第6),IBM的罗曼提(排名第12)和惠普的梅格·惠特曼(排名第15)。上榜的科技界女性总共有16位,还包括谷歌的广告高级副总裁苏珊·沃西基(排名第30)和华为公司董事长孙亚芳(排名第77位)。
Belgium, for example, has less than a tenth of the population of Russia, its rival in the group stage, but is regarded as a far greater threat. And then there is Uruguay, which despite fewer than 4 million citizens -- barely a sixth of the population of greater S?o Paulo -- is one of the teams Brazil would least like to meet on its way to the final. How is this so?

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

凯莉·克莱森、蒂姆·麦格罗、泰勒·斯威夫特、凯莉·安德伍德、米兰达·兰伯特等人的现场表演high翻了米高梅大花园露天剧场。
沃伦·比蒂和费·唐纳薇在宣布奥斯卡最佳影片奖时,因为错拿了评奖结果卡片,误将得奖影片念成了《爱乐之城》,而不是《月光男孩》。事后,负责处理奥斯卡奖项结果的会计公司发了一份公开道歉声明。
10. How to find IP address
《南华早报》援引当地公安局李剑敏告诉新华社记者的消息:“整个加工车间里又腥又臭,人进去待一两分钟就受不了。”

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

There are two concerns about taking a so-called survival job. It could distract you from your job search, and potential employers may have trouble envisioning you in your previous professional role.
Japanese cities have seen a lowering of costs, despite being some of the most expensive cities over the past 20 years, Tokyo and Osaka have dropped to 11th and 14th place, respectively.

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

initially
These larger screen sizes will put additional strain on iOS 7 and developers who will need to figure out how to adapt their apps to even more configurations. These additional formats will provide some exciting opportunities for applications as well, and we can anticipate that iOS 8 will contain many features designed to accommodate multi-screen design.
这些项目一般是为平均年龄22岁的学员设计的。
单词property 联想记忆:
她称自己在成为歌手前本来是想当演员的,不过她的音乐事业先获得了成功。她还说“我感觉自己就像电影《月色撩人》中的雪儿。这是我人生中最精彩的时刻之一。”

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
From the themed collection: 3525套保障房为北京留住更多人才
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

其他国家的监管机构将以日本模式的成功或失败为借鉴。
单词continuous 联想记忆:
“This young Vermonter clearly has an interest in service and anyone putting ideas forward with the goal of making Vermont a better place is appreciated here,” Scott's spokeswoman, Rebecca Kelley, tells PEOPLE.

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

The remarks by Recep Tayyip Erdogan come less than 24 hours before Dutch voters go to the polls in a national election that has been coloured by a heated debate about the role of Islam in Dutch society, spurred by anti-Islam candidate Geert Wilders. Mr Wilders’ Freedom party (PVV) is polling second in the race.
201103/129769.shtml

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
From the themed collection: 京津冀将现“1小时通勤圈”
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

“温家宝总理强调指出,中国有效应对了全球金融危机的严重影响,经济保持稳定快速增长。因此中国成为全球第二大经济体,在五年内GDP几乎翻番。”Luis Schmidt Montes, Chilean ambassador
per全部+spect看+ive→全部看到→看法;眼界;透视
institute

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

A few people took advantage of technology:
这笔交易令17岁的达洛伊西奥成为百万富翁。他在12岁时自学编写软件程序,他将一边继续学业,一边参与雅虎伦敦办事处的工作。
本周一,研究小组表示,根据遗骨可以看出,理查三世患有严重的脊柱侧弯,或者说脊柱弯曲。这会让他十分痛苦,还会导致右肩比左肩高,但莎士比亚的《理查三世》中描述的枯萎的手臂却无从证实。

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

From the themed collection: 家居行业兴起30年 公益之路一起走
Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

单词turkey 联想记忆:

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

对于美联储(Federal Reserve)预计本周宣布的加息已经产生了效应,还是会进一步加大负债企业和经济体所受的压力,投资者意见分歧。

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

2017年我国继续同步提高企业和机关事业单位退休人员的基本养老金水平,惠及1亿多人。
由西班牙IQS商学院、台湾辅仁大学(Fu Jen Catholic University)和旧金山大学(University of San Francisco)三家合办的管理学硕士项目排名升幅最大。其全球创业管理硕士项目的排名上升34位,至第43位,逆转了去年下滑19名的势头。这是唯一一个在三大洲授课的项目,其在国际课程体验方面排名第一。

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

该杂志指出:“特朗普的财富与特朗普大厦和距其一英里范围内的八座建筑紧密相关。在该微小市场所发生的一切,对特朗普净资产的影响超过了世界上其他任何事情,而最近,周边房地产市场已经开始陷入挣扎(相对而言)。”
If you happen to be shy, sitting in the front row can be very uncomfortable at first, but I promise you, it's one of the best ways to pay attention to everything being taught. You can hear better. You can see everything on the board without having to crane your neck around the head in front of you.
Inventors Bryan Carpenter and Bland Hoke were inspired by their passion for the outdoors, and decided to come up with a creative way to bring their hammocks everywhere they go.
The world’s 100 biggest brands still command a significant premium over others and that value increased by 3 per cent to $3.4tn this year, according to the latest BrandZ rankings compiled by Millward Brown, the research agency.

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

['spekju.l?tiv]
STEP 5: GET RID of most of your friends

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

The untitled movie revolves around two intersecting love triangles, obsession and betrayal, set against the music scene. It stars Christian Bale, Cate Blanchett, Michael Fassbender, Ryan Gosling, Rooney Mara and Natalie Portman.
awkward

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

开发商:Remedy Entertainment、Microsoft Studios

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
From the themed collection: 湖北陶瓷行业有产量无品牌很尴尬
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

consciousness
大力优化外商投资环境。
unexpectedly
Wang Ki-young, a director at South Korea’s culture ministry, said on Friday that Chinese authorities had ordered tourism agencies in Beijing to halt tours to South Korea from mid-March. Mr Wang said the move would be expanded to other provinces.

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

They're developing a core and sorting through roles. Because they're the Lakers, there remains the possibility that a solid free agent or two will look their way.
The Sixers are still slowly pivoting from a full-on institutional tank job to trying to be competitive, and the Suns are not expecting to be anything like good. So those two teams are quasi-tanking. They are, at least, not mad about losing.

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

The “cool” factor isn’t the only issue. Security and privacy, particularly around the management of consumer data, remain a concern as the tech industry seeks to bring more of our body parts online. As The Economist notes, the glamour of developing sensors and algorithms for wearables is distracting everyone from glaring missing elements, “standards, interoperability, integration and data management” and “intellectual-property rights and regulatory compliance” among them. All this in an environment where paranoia remains over the National Security Administration’s activities.
然而,这可能被欧洲和中国的投资下滑抵消,如果中国打算在一定程度上由投资于资源耗费高的建设项目,转向投资于水净化等对大宗商品依赖不强的基础设施项目,那么中国投资对全球贸易的影响将会加大。
我们将尚未生长成型的水果放进模子里。

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
From the themed collection: 合肥楼市发新政 南京房价仍火爆
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

当年秋天开学后,达洛伊西奥开始感觉到肩上背负起了来自投资方的巨大压力。他需要改善软件的运算法则,于是他找到了以色列一个从事自然语言处理的编程团队,并签订了合同。他还用谷歌(Google)搜索找到了一位居住在泰国、在该领域有过重要著作的退休教授。达洛伊西奥说,他成了我们的科研主管,他现在在雅虎的森尼维尔办公室工作。
Because of her success, she no longer lives anything resembling a normal life.
Learn to tweet. Your boss expects it

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

vt. 监禁,下狱
['rep?twɑ:]

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

榜单前十位还包括:第五名的亚马逊总裁杰夫·贝佐斯,第六名的Facebook的马克·扎克伯格,位居第七的甲骨文公司老板拉里·埃里森,第八名的迈克尔·彭博及并列第九的科赫兄弟(大卫·科赫和迈克尔·科赫)。
In 2014, the actress Tilda Swinton wore false teeth in four movies: “The Zero Theorem,” “The Grand Budapest Hotel,” “Only Lovers Left Alive” and “Snowpiercer,” a film directed by Bong Joon-ho. In this thriller, Ms. Swinton plays the cruel and calculating Minister Mason, distinguished by a giant pair of glasses and a mouthful of bulky, misshapen choppers.
然而,北方高等商学院毕业生的国际化流动程度最高,2014届毕业生有85%曾在国外工作。

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

Meanwhile, villages within the city's boundaries will be overhauled and low-end manufacturers and logistics companies removed.
在丝绸之路上找到了一个1700年历史之久的墓地。丝绸之路是一系列的古代贸易路线,曾经链接着中国和罗马帝国。

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

12月份以美元计的进口同比增长3.1%至1686亿美元,而上个月修正后的增幅为4.7%(修正前为6.7%)。这一增长幅度大致符合3%预期中数。
So with such a strong South American contingent, where will the main challenge come from ? Well, the big guns from Europe is the obvious answer. And where else could you look for a team of Champions than Spain. Having won the last World Cup, sandwiched between two European Championship triumphs, this is a team that not only knows how to play fantastic football, but that knows how to win. So whilst Messi and Ronaldo get all the annual plaudits and player of the year titles, the likes of Xavi and Iniesta go about winning all the major trophies. So will they be as string this year ? Well, worryingly for the rest of the world, yes. Not only are most of the old guard still there but talented youngsters such as Koke and Thiago Alcantara have joined the ranks. Not only that, but they've managed to grab a prolific striker, Diego Costa, from under the noses of the host nation, with the Atletico Madrid forward opting to play for Spain, rather than the nation of his birth.
受到好的affect影响就充满爱affection,受到不好的影响affect就学会假装affected

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

We will accelerate the development of emerging industries.

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
From the themed collection: 绿色,水泥混凝土发展的必然出路
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

Saif held the highest position among the five ranked Chinese schools, just ahead of Guanghua School of Management and Tsinghua University School of Economics and Management, 17th and 18th respectively.
Shortly after Cook's op-ed, the Senate voted to approve the Employment Non-Discrimination Act, which would make it illegal to discriminate against LGBT employees in the workplace. The legislation will now be sent to the House for consideration.

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

《死侍》将于2016年2月12日爆笑上映。 当然,电影中还有不少动作和杀戮场景。
尽管这些大脑没有进入任何人的身体,但是他们给科学院研究脑科疾病提供了原材料。

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

13. iPhone Reminders
郭晶晶与霍启刚(香港近代富豪霍英东的孙子)的秘密恋情已经引起了全民的想象,人们似乎在关注运动员赛场表现之余,也愈加关心起他们的私人生活了。

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
From the themed collection: 24个月后 北京再供纯商品住宅地块
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

北京2016年受理外籍人士及其家属永久居留申请较2015年增长426%。
For the students interested in comparing school options around the world, US News released the fourth edition of its annual Best Global Universities rankings.

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
From the themed collection: 取消“公摊面积”行不行
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

《胡润百富榜》的编制者胡润(Rupert Hoogewerf,见文首图)表示:“姚振华代表了中国金融投资创造财富的新浪潮。”

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

The Peoria, Ill.-based maker of heavy equipment authorized $10 billion in stock repurchases in January and expected to buy back $1.7 billion of its shares in the first quarter this year to complete its previous $7.5 billion repurchase initiative. The ongoing buybacks are "a result of our record cash flow," said CEO Doug Oberhelman.
一位毕业生表示:“伦敦商学院拓宽了我的专业视野,开启了国际职业机遇。”他补充称:“在毕业后的3年里,我在美国、加拿大和香港工作过,辗转于公司银行业务、债务资本市场等多个领域。”
即使我们把吉布森视作租赁合同并且他将在夏天离开,雷霆对这笔交易依然感觉良好。
最后,今年只有两所学校首次登上开放课程排行榜。上海交通大学安泰经济与管理学院(Antai College of Economics and Management)直接排到第32名,而亚利桑那大学(University of Arizona)艾勒管理学院(Eller College of Management)在75所院校中排名第68位。

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
From the themed collection: 尚品宅配陷“高毛利低净利”尴尬
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

本文为与《时代》杂志的合作内容。

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

Most popular vehicle
Russia's economy is the 10th largest in the world, producing little of value beyond hydrocarbons. Corruption and rent-seeking extract an enormous economic toll. It remains burdened with Soviet era infrastructure, and its ability to meet the educational and medical needs of its population is rapidly declining.
卓越雇主排名:59

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
From the themed collection: 住房变迁获得感满满
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

实话说没有其他国家能拥有中国那样的优厚研究条件:一个有着长期明确财政支持和庞大国内市场的政府——尽管大部分市场并不自由。市场预计中国国内航空市场将在当前基础上翻四倍,到2036年乘客总数将两倍于美国,达到16亿人次。
《大空头》,导演:亚当·麦凯。

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

Bill Gates topped the list of the world's richest billionaires for the 17th time in 22 years, it has been revealed.
contribution

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
From the themed collection: 板材国标升级任重道远
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

Lecent was with an unknown number of other youth when she was killed by a single bullet inside a home in a public-housing complex near Martin Grove Rd. and Finch Ave W.

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

According to the announcement, the new administrative center in Tongzhou will put infrastructure upgrades and ecological improvement on top of the agenda. The municipal government hopes to improve public services in education, healthcare, cultural events and industries in the district.
另有其他四部国产电影挤入榜单前十位,排名第三的是《羞羞的铁拳》,第四名为《功夫瑜伽》,第五名为《西游伏妖篇》,第八名为《芳华》。
年龄:46

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
From the themed collection: 浙民投与佳兆业“生化”危机再起
Paper

Length-scale dependence of protein hydration-shell density

2011年诺贝尔和平奖被授予利比利亚总统埃伦.约翰逊.瑟利夫,利比利亚和平活动人士蕾曼.格鲍伊和也门妇女权利倡导者塔瓦库尔.卡门。
周三,北京市发改委主任卢彦在新闻发布会上说:“我们将会在通州开展297个项目,例如建设地铁线和高速路及改善生态环境。”
The biggest falls in brand values include oil and gas companies, still suffering from low commodity prices, and banks, which face growing competition from rival payment systems such as PayPal — whose brand value increased by 35 per cent (see story page 2).
英国脱欧带来的贸易不确定性

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

fare
然而,夏威夷航空公司公共关系高级专家休伊·沃(Huy Vo)说,占据该公司半数以上航线的短途航班实际上运营并不容易。他表示,“我们的地理位置确实给我们带来了优势,也给我们带来了短途航线。不过,这些短途航线最难保持准时到达,因为飞行距离很短,航班在地面的停留时间也短,因此任何延误都会难以弥补。”

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

If you’re looking for a free CRM system, Zoho is probably the one for you. Why? It comes down to the integration possibilities. For example, Zoho integrates with JotForm and Unbounce simply by adding your API key. This means that within seconds, web leads will automatically be sent to your CRM. Pretty powerful for being free.
Beijing ranked No 3 on the list of top 10 most congested cites in China, following Jinan and Harbin, according to a report by China Academy of Transportation Sciences.
Prince Miteb, who headed the powerful National Guard until early November, was released on November 28th, the official said. At least three other suspects have also finalized settlement deals.

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
From the themed collection: 环保建材助力建筑行业可持续发展
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Harvey C Mansfield, one of Harvard's most outspoken conservative professors and the author of a book called Manliness, also told the Guardian he questioned the decision. "The bounds of what is offensive have been extended and distorted, and I no longer trust the bent judgment of politically correct enforcers."
然而,在毕业3年后,担任部门负责人或以上级别职位的女性(59%)显著少于男性(68%)。

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