Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
When faced with competition, they may focus less on winning or losing than their Type A counterparts, and more on enjoying the game regardless of winning or losing.
Most technology developers are seeing app use grow and web use decline. That means companies have to have strong, fast, meaningful mobile platforms and those that don't lose customers.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
4. Precious metals: 'Going dark! Economic cycles point downward'
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
As a national exam with more than 1 million test takers every year, the National Postgraduates Entrance Examination is very important for students' academic life, and cheating incidents have been exposed from time to time.
China becomes the first middle-income country to join the ranks of the world's 25 most-innovative economies, according to the Global Innovation Index (GII) released last Monday.
Trends and targets in antiviral phototherapy
《一位德国女权主义先锋在痛苦中回顾过去》(A Pioneering German Feminist Looks Back in Anguish)
A child prodigy with an IQ higher than Albert Einstein is celebrating becoming a unique member of Mensa. Nishi Uggalle, ten, is one of the youngest people in the country to score the highest possible mark of 162 in the IQ society's supervised testing.
有些热门剧已经走得太远，应该降降温了，却仍在大张旗鼓，比如《唐顿庄园》(Downton Abbey)、《丑闻》(Scandal)和《复仇》(Revenge)。ABC频道的新剧《逍遥法外》(How to Get Away With Murder)是一部有趣的替代品，它是一部耸人听闻的夜间肥皂剧，讲述不法辩护律师的故事，简直可以称为“法律与无序”。
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
1.《刺客聂隐娘》(The Assassin)与《疯狂的麦克斯4：狂暴之路》(Mad Max: Fury Road)，并列。侯孝贤和乔治·米勒(George Miller)导演了今年最好的两部商业片，二者都应该到你能找到的最大的屏幕上去看。
ACE2 as a potential therapeutic target for pandemic COVID-19
In addition, the 1980 stamps were designed by Huang Yongyu, 92, a well-known Chinese master painter, making it a collectible item with extreme value.
Diagnostic technologies for COVID-19: a review
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
4. The 2012 Ig Nobel Neuroscience Prize
Three Billboards Outside Ebbing, Missouri is a darkly comic drama from Academy Award winner Martin McDonagh.
库什纳回忆道，我当时被他深深折服了。他到新闻集团去见默多克时，我与他有了第一次接触，当时我被一同叫去提提意见。达洛伊西奥在会上描述了他想要实现的远景。他帮助默多克加深了对一些事物的见解。达洛伊西奥在台上的优异表现，加上背后李嘉诚的雄厚财力，为Summly招来了包括艾什顿?库奇(Ashton Kutcher)、小野洋子(Yoko Ono)、史蒂芬?弗莱(Stephen Fry)等许多人的捐赠。
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Dachis says: Adidas added more than 34 million new fans and followers in just 12 months this year. The company put that audience to good use and benefited from high levels of positive discussion all year long.
Wang Jie, the general manager of a Beijing-based investment company, said the higher pay for executives in the financial and real estate industries shows the imbalance of development in China.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
As consumers in developing countries continue to shift to meat-based diets, grains and oilseeds used as livestock feed are expected to see support.
Antiviral drug discovery: broad-spectrum drugs from nature
不过目前来看，这些潜在的乌云似乎都没有遮住特斯拉在帕洛阿尔托总部的阳光。特斯拉仍然坚持在2020年之前年产50万辆汽车的中期目标。这在很大程度上要取决于Model X是否有能力维持当前的势头。特斯拉已经大大提高了资本和研发支出，以确保Model X的顺利发布（虽然已经推迟了一年）。
She had recently emerged as the right hand of her father, the former Prime Minister Nawaz Sharif. But corruption charges are clouding her rapid rise.
Influenza neuraminidase: A druggable target for natural products
It was visible in practically every brand that edged from the 1960s to 1970s for the season currently in stores, including Alberta Ferretti, Pucci and Etro.
7.Make Practice Tests
Housing started last year on a high note. It ended the year facing mounting worries about higher interest rates, supply constraints, tight credit and a host of other problems.
The actress who kick-started the exposure of Hollywood moguls who allegedly exploited positions of power to abuse women has branded #MeToo campaigners against sex attackers 'losers'.
“The auction market is extremely selective,” said Henry Pettifer, the head of old master paintings at Christie’s, whose sale total had been dented by a 15th-century Flemish Madonna and child by Hans Memling that the auction house had sold privately for more than 3.5 million and had withdrawn from the sale. “The availability of fresh material is limited,” he added, alluding to how few museum-quality works are in private hands.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
The findings of the US and UK scientists are based on thousands of global temperature measurements taken daily on land and at sea.
The role of biosensors in the detection of emerging infectious diseases
The other two manufacturers, OPPO and vivo, both achieved growth of over 100 percent, shipping 99.4 million and 77.3 million units respectively in 2016.
Quantitative determination of mechanical stability in the novel coronavirus spike protein
P2P lending has grown quickly in the past two years, with loans outstanding reaching Rmb209bn by the end of June, according to E-Lending House.
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
This groundbreaking fight is loosely based on a bout between Chuck Wepner and Muhammad Ali, in which the "everyman" Wepner managed to become one of the four men to knock Ali down in his career. Just like in the film, Wepner pushed Ali through 15 rounds despite looking (and feeling) like he'd been hit by a truck. While both he and Rocky ended up losing their fights on a technicality, Wepner wins in our book for inspiring such an awesome character.
Song “Chang’er”(Li Yugang and three Chinese astronauts)
Belgium, for example, has less than a tenth of the population of Russia, its rival in the group stage, but is regarded as a far greater threat. And then there is Uruguay, which despite fewer than 4 million citizens -- barely a sixth of the population of greater S?o Paulo -- is one of the teams Brazil would least like to meet on its way to the final. How is this so?
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
10. How to find IP address
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
There are two concerns about taking a so-called survival job. It could distract you from your job search, and potential employers may have trouble envisioning you in your previous professional role.
Japanese cities have seen a lowering of costs, despite being some of the most expensive cities over the past 20 years, Tokyo and Osaka have dropped to 11th and 14th place, respectively.
Inhibition of SARS coronavirus helicase by bismuth complexes
These larger screen sizes will put additional strain on iOS 7 and developers who will need to figure out how to adapt their apps to even more configurations. These additional formats will provide some exciting opportunities for applications as well, and we can anticipate that iOS 8 will contain many features designed to accommodate multi-screen design.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
“This young Vermonter clearly has an interest in service and anyone putting ideas forward with the goal of making Vermont a better place is appreciated here,” Scott's spokeswoman, Rebecca Kelley, tells PEOPLE.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
The remarks by Recep Tayyip Erdogan come less than 24 hours before Dutch voters go to the polls in a national election that has been coloured by a heated debate about the role of Islam in Dutch society, spurred by anti-Islam candidate Geert Wilders. Mr Wilders’ Freedom party (PVV) is polling second in the race.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
“温家宝总理强调指出，中国有效应对了全球金融危机的严重影响，经济保持稳定快速增长。因此中国成为全球第二大经济体，在五年内GDP几乎翻番。”Luis Schmidt Montes, Chilean ambassador
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
A few people took advantage of technology:
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
由西班牙IQS商学院、台湾辅仁大学(Fu Jen Catholic University)和旧金山大学(University of San Francisco)三家合办的管理学硕士项目排名升幅最大。其全球创业管理硕士项目的排名上升34位，至第43位，逆转了去年下滑19名的势头。这是唯一一个在三大洲授课的项目，其在国际课程体验方面排名第一。
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
If you happen to be shy, sitting in the front row can be very uncomfortable at first, but I promise you, it's one of the best ways to pay attention to everything being taught. You can hear better. You can see everything on the board without having to crane your neck around the head in front of you.
Inventors Bryan Carpenter and Bland Hoke were inspired by their passion for the outdoors, and decided to come up with a creative way to bring their hammocks everywhere they go.
The world’s 100 biggest brands still command a significant premium over others and that value increased by 3 per cent to $3.4tn this year, according to the latest BrandZ rankings compiled by Millward Brown, the research agency.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
STEP 5: GET RID of most of your friends
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
The untitled movie revolves around two intersecting love triangles, obsession and betrayal, set against the music scene. It stars Christian Bale, Cate Blanchett, Michael Fassbender, Ryan Gosling, Rooney Mara and Natalie Portman.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
开发商：Remedy Entertainment、Microsoft Studios
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Wang Ki-young, a director at South Korea’s culture ministry, said on Friday that Chinese authorities had ordered tourism agencies in Beijing to halt tours to South Korea from mid-March. Mr Wang said the move would be expanded to other provinces.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
They're developing a core and sorting through roles. Because they're the Lakers, there remains the possibility that a solid free agent or two will look their way.
The Sixers are still slowly pivoting from a full-on institutional tank job to trying to be competitive, and the Suns are not expecting to be anything like good. So those two teams are quasi-tanking. They are, at least, not mad about losing.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
The “cool” factor isn’t the only issue. Security and privacy, particularly around the management of consumer data, remain a concern as the tech industry seeks to bring more of our body parts online. As The Economist notes, the glamour of developing sensors and algorithms for wearables is distracting everyone from glaring missing elements, “standards, interoperability, integration and data management” and “intellectual-property rights and regulatory compliance” among them. All this in an environment where paranoia remains over the National Security Administration’s activities.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Because of her success, she no longer lives anything resembling a normal life.
Learn to tweet. Your boss expects it
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
In 2014, the actress Tilda Swinton wore false teeth in four movies: “The Zero Theorem,” “The Grand Budapest Hotel,” “Only Lovers Left Alive” and “Snowpiercer,” a film directed by Bong Joon-ho. In this thriller, Ms. Swinton plays the cruel and calculating Minister Mason, distinguished by a giant pair of glasses and a mouthful of bulky, misshapen choppers.
A modular microarray imaging system for highly specific COVID-19 antibody testing
Meanwhile, villages within the city's boundaries will be overhauled and low-end manufacturers and logistics companies removed.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
So with such a strong South American contingent, where will the main challenge come from ? Well, the big guns from Europe is the obvious answer. And where else could you look for a team of Champions than Spain. Having won the last World Cup, sandwiched between two European Championship triumphs, this is a team that not only knows how to play fantastic football, but that knows how to win. So whilst Messi and Ronaldo get all the annual plaudits and player of the year titles, the likes of Xavi and Iniesta go about winning all the major trophies. So will they be as string this year ? Well, worryingly for the rest of the world, yes. Not only are most of the old guard still there but talented youngsters such as Koke and Thiago Alcantara have joined the ranks. Not only that, but they've managed to grab a prolific striker, Diego Costa, from under the noses of the host nation, with the Atletico Madrid forward opting to play for Spain, rather than the nation of his birth.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
We will accelerate the development of emerging industries.
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Saif held the highest position among the five ranked Chinese schools, just ahead of Guanghua School of Management and Tsinghua University School of Economics and Management, 17th and 18th respectively.
Shortly after Cook's op-ed, the Senate voted to approve the Employment Non-Discrimination Act, which would make it illegal to discriminate against LGBT employees in the workplace. The legislation will now be sent to the House for consideration.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
13. iPhone Reminders
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
For the students interested in comparing school options around the world, US News released the fourth edition of its annual Best Global Universities rankings.
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
The Peoria, Ill.-based maker of heavy equipment authorized $10 billion in stock repurchases in January and expected to buy back $1.7 billion of its shares in the first quarter this year to complete its previous $7.5 billion repurchase initiative. The ongoing buybacks are "a result of our record cash flow," said CEO Doug Oberhelman.
最后，今年只有两所学校首次登上开放课程排行榜。上海交通大学安泰经济与管理学院(Antai College of Economics and Management)直接排到第32名，而亚利桑那大学(University of Arizona)艾勒管理学院(Eller College of Management)在75所院校中排名第68位。
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Most popular vehicle
Russia's economy is the 10th largest in the world, producing little of value beyond hydrocarbons. Corruption and rent-seeking extract an enormous economic toll. It remains burdened with Soviet era infrastructure, and its ability to meet the educational and medical needs of its population is rapidly declining.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Bill Gates topped the list of the world's richest billionaires for the 17th time in 22 years, it has been revealed.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Lecent was with an unknown number of other youth when she was killed by a single bullet inside a home in a public-housing complex near Martin Grove Rd. and Finch Ave W.
Anti-HIV drug repurposing against SARS-CoV-2
According to the announcement, the new administrative center in Tongzhou will put infrastructure upgrades and ecological improvement on top of the agenda. The municipal government hopes to improve public services in education, healthcare, cultural events and industries in the district.
Length-scale dependence of protein hydration-shell density
The biggest falls in brand values include oil and gas companies, still suffering from low commodity prices, and banks, which face growing competition from rival payment systems such as PayPal — whose brand value increased by 35 per cent (see story page 2).
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
If you’re looking for a free CRM system, Zoho is probably the one for you. Why? It comes down to the integration possibilities. For example, Zoho integrates with JotForm and Unbounce simply by adding your API key. This means that within seconds, web leads will automatically be sent to your CRM. Pretty powerful for being free.
Beijing ranked No 3 on the list of top 10 most congested cites in China, following Jinan and Harbin, according to a report by China Academy of Transportation Sciences.
Prince Miteb, who headed the powerful National Guard until early November, was released on November 28th, the official said. At least three other suspects have also finalized settlement deals.
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Harvey C Mansfield, one of Harvard's most outspoken conservative professors and the author of a book called Manliness, also told the Guardian he questioned the decision. "The bounds of what is offensive have been extended and distorted, and I no longer trust the bent judgment of politically correct enforcers."